张蕊，校聘副教授

研究方向：乳腺肿瘤干细胞与肿瘤微环境互作研究

电子邮箱：zhangrui@ahmu.edu.cn

办公室：药学科学学院（临床药理研究所）311

教育经历：

(1) 2014-09至2019-06，中国科学技术大学，生物物理，硕博连读

(2) 2010-09至2014-06，安庆师范大学，生物科学，学士

工作经历：

(1) 2023-03至今，det365登录网站主页，临床药理研究所，校聘副教授

(2)2019-12至2023-02，复旦大学，附属肿瘤医院 博士后

主持课题项目情况：

（1）国家自然科学基金委员会，青年项目，CCR6通过增强PMN-MDSC富集和免疫抑制能力促进三阴性乳腺癌进展的机制研究（82403663），2025-01-01至2027-12-31，30万元，在研，主持；
（2）国家自然科学基金委员会，重点项目，乳腺癌生态系统中调控乳腺癌化疗耐药的关键分子及其功能机制研究（82230103），2023-01-01至2027-12-31，261万元，在研，参与；

（3）安徽省教育厅，重点项目，CCR6+多形核髓源性抑制细胞促进乳腺肿瘤干细胞自我更新的机制研究（2024AH050776），2025-01-01至2027-12-31，10万元，在研，主持。

发表论文情况：

(1) Rui Zhang*; Mengxue Dong*; Juchuanli Tu; Fengkai Li; Qiaodan Deng; Jiahui Xu; Xueyan He; Jiajun Ding; Jie Xia; Dandan Sheng; Zhaoxia Chang; Wei Ma; Haonan Dong; Yi Zhang; Lixing Zhang; Lu Zhang; Suling Liu ; PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway, Signal Transduction and Targeted Therapy, 2023, 8(1): 97 98 (IF：40.80)

(2) Rui Zhang*; Juchuanli Tu*; Suling Liu ; Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity, Seminars in Cancer Biology, 2021, 205(5) (IF：15.707)

(3)Rui Zhang; Jun Wang; HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells, Cancer Science, 2018, 109(8): 2446-2457. (IF：6.716)

(4) Caiqi Xu; Yaoyao Wu; Sui Yang; Xuechun Zhao; Hao Zhang; Xuechun Zhao; Jiemin Zhao; Wei Wei; Qian Meng; Yujuan Wang;Rui Zhang,Inhibition of DJ-1 induces TFAM secretion from cancer cells to suppress tumor growth via promoting M1 macrophage polarization,Cellular Signalling,2025,131:111765. (通讯作者，IF:4.4)

(5) Dandan Sheng*; Wei Ma*; Rui Zhang*; Lei Zhou; Qiaodan Deng; Juchuanli Tu; Wankun Chen; Fuchuang Zhang; Nailong Gao; Mengxue Dong; Dong Wang; Fengkai Li; Yin Liu; Xueyan He; Shengzhong Duan; Lixing Zhang; Tong Liu; Suling Liu ; Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization, Journal for ImmunoTherapy of Cancer, 2022, 10(5): e003793-e003793.(共同第一作者，IF：12.469)

(6) Fan Tang*; Rui Zhang*; Jun Wang ; Cyclooxygenase-2-Mediated Up-Regulation of Mitochondrial Transcription Factor A Mitigates the Radio-Sensitivity of Cancer Cells, International Journal of Molecular Sciences, 2019, 20(5): 0-1218.(共同第一作者，IF：5.924)

(7) Qian Meng*, Meng-hui Guo*, Rui Zhang*, Jing Wei, Qian Chen, Xue-chun Zhao, Cai-qi Xu, Yao-yao Wu, Jia-jie Kuai,Jie-min Zhao, Yu-jing Wu, Chong-huan Ye, Hong-rui Wei, Xia Zhu, Yan Jin, Zhi Zhang, and Wei Wei; G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway,Acta Pharmacologica Sinica; 2025;0:1–13. (共同第一作者，IF：8.20)

(8) Jiahui Xu, Xiaoli Yang, Qiaodan Deng, Cong Yang, Dong Wang, Guojuan Jiang, Xiaohong Yao, Xueyan He,Jiajun Ding, Jiankun Qiang, Juchuanli Tu, Rui zhang, Qun-Ying Lei, Zhi-min Shao, Xiuwu Bian,Ronggui Hu, Lixing Zhang & Suling Liu; TEM8 marks neovasculogenic tumor-initiating cellsin triple-negative breast cancer, Nature Communications; 2021; 12:4413. (IF：15.7)

(9) Jie Xia, Lixing Zhang, Xilei Peng, Juchuanli Tu, Siqin Li, Xueyan He, Fengkai Li, Jiankun Qiang,Haonan Dong, Qiaodan Deng, Cuicui Liu, Jiahui Xu, Rui Zhang, Quentin Liu, Guohong Hu,Chong Liu, Yi-Zhou Jiang, Zhi-Ming Shao, Ceshi Chen and Suling Liu; IL1R2 Blockade Alleviates Immunosuppression andPotentiates Anti-PD-1 Efficacy in Triple-Negative BreastCancer;Cancer Research, 2024;84:2282-96. (IF：13.4)