崔昊，药物化学博士，校聘副教授，硕士研究生导师

研究方向：小分子药物的设计、合成及生物活性研究

电子邮箱：cuih1008@ahmu.edu.cn

主要科研项目：

1. 国家自然科学基金青年基金项目（C类），82504597，2026/1-2028/12，在研，主持；

2. 安徽省高校自然科学研究项目，2022AH050654，2023/1-2024/12，结题，主持。

主要发表论文：

1. Hao Cui*, Xu Huang, Rui Li, Yadong Chen, Tao Lu*, Yong Zhu*, et.al. Design and Synthesis of Novel N-(1H-pyrazol-3-yl)pyrimidin-4-amine Aurora/HDAC Dual Inhibitors for Colorectal Cancer Treatment. . Journal of Medicinal Chemistry. 2025, 68(22): 23941-23961. (IF: 6.8,一区Top）

2. Hao Cui, Guodong Zhang, Liyuan Zhang, Tao Lu*, Lei Zhang*, Yong Zhu*, et.al. Discovery of N-phenyl-5-propyl-1H-pyrazole-3-carboxamide, with selective inhibition and degradation of HDAC6 for the treatment of acute liver injury. Journal of Medicinal Chemistry. 2025, 68(1): 531-554. (IF: 6.8,一区Top）

3. Hao Cui^#, Qianqian Hong^#, Ran Wei, Tao Lu*, Yadong Chen*, Yong Zhu*, et.al. Design and synthesis of HDAC inhibitors to enhance the therapeutic effect of diffuse large B-cell lymphoma by improving metabolic stability and pharmacokinetic characteristics. European Journal of Medicinal Chemistry. 2022 229: 114049.（IF: 5.9,1区）

4. Hao Cui, Jingkun Huang, Yan Lei, Tao Lu*, Yong Zhu*, Yatian Huang*, et.al. Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumour cancer. European Journal of Medicinal Chemistry. 2022 229: 114082.（IF: 5.9,1区）

5. Hao Cui^#, Zan Hu^#, Kang Yang, Tao Lu*, Yuqin Yao*, Yong Zhu*, et.al. Design and synthesis of highly TRAIL expression HDAC inhibitors based on ONC201 to promote apoptosis of colorectal cancer. European Journal of Medicinal Chemistry. 2022 238: 114568.（IF: 5.9,1区）

6.Rui Li, Xu Huang, Rui Wang, Tao Lu*, Yan Sun*, Hao Cui*, et.al. Targeting KRAS^G12C mutation: development of effective strategies to overcome drug resistance and limited efficacy. European Journal of Medicinal Chemistry. 2025 294: 117718.（IF: 5.9,1区）

7. Xu Huang, Rui Li, Meng Zong, Yong Zhu*, Yan Sun*, Hao Cui*. Targeting NF-κB-inducing kinase (NIK) in the non-canonical pathway: Advances in the development of NIK inhibitors. Bioorganic Chemistry.2025 167:109247.（IF: 4.7,1区）

8. Guo-dong Zhang, Li-li Wang, Ling Zheng, Bao-ming Wu*, Hao Cui*, Lei Zhang*, et.al. A novel HDAC6 inhibitor attenuate APAP-induced liver injury by regulating MDH1-mediated oxidative stress. International Immunopharmacology. 2024 131:111861.（IF: 4.7）

发表专利情况：

（1）崔昊；黄旭；孙岩；李锐；纵猛；王蕊；陈秋萍，苯并咪唑类化合物及其制备方法、药物组合物和应用，2026-01-13，中国，专利申请号：202511730022.8

（2）崔昊；孙岩；黄旭；李锐；王蕊，三苯基膦类化合物及其制备方法、药物组合物和应用，2025-07-04，中国，专利申请号：202510400962.4

（3）陆涛，崔昊，陈亚东，朱雍，吴照球，李红玫，陈泉威，魏然，Snail抑制剂及其衍生物，制备方法、药物组合和应用。2023-02-01，中国，专利号：ZL202010329903.X